58. How should we implement slowing aging and rejuvenation?

Slowing aging reduces the rate of deleteriome accumulation; rejuvenation shifts the system to a lower biological-age state. In practice, substantial longevity gains may require both lowering the long-term rate of burden accumulation and periodically resetting or replacing the most limiting components before they cross failure thresholds. There are also safety and ethical limitations. Many approaches to exceptional longevity would require major changes in otherwise healthy individuals, carrying a risk of complications or even death. This creates a difficult risk-benefit dilemma: is it rational to apply such approaches to achieve possible future benefits if doing so introduces immediate morbidity or mortality risk today?