2. Embryonic Rejuvenation May Offer Principles for Adult Rejuvenation

Embryonic rejuvenation shows that biology can execute a deep reset in which biological age decreases to a minimum (ground zero) before the organism begins its lifelong rise in deleteriome. Mechanistically, this universal natural rejuvenation process is not yet understood. Translating this to adults will likely require inducing selected components of the developmental reset (damage clearance, epigenomic rebuilding, and coordinated tissue remodeling), without erasing cellular identity or disrupting the control of tumorigenesis.