50. Would progress come from individual labs or large, collaborative efforts?

Individual labs provide agility for innovative hypotheses, while large collaborations tackle scale, so it is better to use the following model: large consortia to build maps, cohorts, and tools; individual labs to probe bold approaches and mechanisms. The field should support multi-institutional cores and fast-track data access, while supporting for high-risk, high-reward studies in individual labs. Hybrid models, with core teams and satellite innovators and adversarial consortia, could drive the field forward while limiting bureaucracy.