Simply Aging

IV. Targeting Aging in Practice

What it means to slow aging, and what works today.

  1. 1.Slowing Aging Means Durably Reducing the Rate of Deleteriome Increase
  2. 2.Large Lifespan Gains May be Easier to Obtain in Model Organisms than in Humans
  3. 3.Natural Species Longevity and Lab-Achieved Longevity Are Mechanistically Distinct
  4. 4.Caloric Restriction Can Slow Aging in a Context-Dependent Manner
  5. 5.Mean Lifespan Can be Increased by Targeting Weak Links and Reducing Fluctuations
  6. 6.Lifespan Plasticity Reflects System-Level Tuning of Damage, Maintenance, and Buffering
  7. 7.Lifespan Interventions Can Differ in Effect between Males and Females
  8. 8.Longevity Interventions Should be Personalized
  9. 9.Longevity Interventions Likely Matter Most Before Dominant Failures Are Established
  10. 10.Medical and Public Health Advances Have Already Extended Human Life Expectancy
  11. 11.Practical Lifespan Gains Today Come from Reducing Risk and Preserving Function
  12. 12.Strong Evidence for Slowed Aging in Humans Must Show Durable, Multilevel Benefit